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Ethical Issues Related to Study Design for Trials on Therapeutics for Ebola Virus Disease

2014

This report summarizes the discussions of the Ethics Working Group of the World Health Organization (WHO) that included statisticians, methodologists, drug regulators, researchers, ethics committee members, and delegates from communities in West Africa affected by Ebola virus disease. The participants of the meeting convened to learn about clinical trial designs for Ebola virus disease, conduct ethical analyses of the available study design options, and provide advice on the relevant ethical considerations for utilizing various study designs. This resulting document from the meeting includes a decision matrix that takes into account many of the issues and considerations for all of the study design options; this matrix can be used by investigators, ethics committees, or other stakeholders when developing research studies.

Source:

Ethical Issues Related to Study Design for Trials on Therapeutics for Ebola Virus Disease: WHO Ethics Working Group Meeting. World Health Organization 2014. https://apps.who.int/iris/handle/10665/137509.