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Expert Consultation on the Use of Placebos in Vaccine Trials

2013

This report from the World Health Organization (WHO) summarizes an expert consultation meeting on the use of placebo in vaccine trials. The meeting participants examined the ethical issues in three main categories: overarching ethical principles relevant for all research studies, ethical issues relevant to placebo-controlled trials in general, and ethical issues specific to placebo-controlled vaccine trials when an efficacious vaccine against the condition under study already exists. A placebo-controlled trial is a common model for evaluating a new vaccine when there is no existing vaccine – in this meeting, experts discussed acceptability of use of placebos and identified situations where the conduct of a placebo-controlled trial may be justified. They also proposed procedural and substantive recommendations directed towards sponsors, researchers, research ethics committees, public health authorities, and policymakers.

Source:

Expert Consultation on the Use of Placebos in Vaccine Trials: Meeting Report. World Health Organization 2013.  https://apps.who.int/iris/handle/10665/94056.